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Oxidative stress may play a key role in development of diabetic complications. Prooxidants activities are inhibited by zinc as Zinc is the first non-protein antioxidant. The aim of this study is to measure serum, fasting plasma zinc values in patients with type 2 diabetes mellitus and examine the effect of zinc supplementation on plasma zinc levels in the same patients. Serum, fasting plasma zinc levels in 47 patients with type 2 diabetes mellitus were evaluated. The patients were randomized into 2 groups. They were treated with zinc sulphate 100 mg/day (group I, 22 patients, male: female ratio, 2:1) or a placebo (group II, 25 patients, male: female ratio, 3:2) for 4 months. Fasting plasma zinc levels were measured at baseline, during the first and last month of the study in patients with zinc supplementation. Mean fasting plasma zinc concentrations were 11.2 mg/dl (SD: 3.1) at baseline, 11.7 mg/dl (SD: 3.1) at the first month (p In vivo treatment of herpes simplex virus infection with imidazoquinoxaline.
A Schiff base derivative of quinoxaline (ImZnQ) was examined for its activity against herpes simplex virus (HSV) in immunosuppressed mice. ImZnQ had a high activity against HSV-1 at 2 and 4 mg/kg ip, and this activity was maintained in mice infected with this virus at 6 and 8 mg/kg ip. In contrast,
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